Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1, was involved in enhancing early glycolytic flux during inflammatory macrophage polarization.
[Cell Reports]
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Bae, S., Park, P. S. U., Lee, Y., Mun, S. H., Giannopoulou, E., Fujii, T., Lee, K. P., Violante, S. N., Cross, J. R., & Park-Min, K.-H. (2021). MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Reports, 35(11). https://doi.org/10.1016/j.celrep.2021.109264 Cite
