Scientists treated HaCaT cells which resembled human epidermis with IC50 concentration of all-trans-Retinoic Acid-spermine conjugate and analyzed their miRNA expression profile.
[Pharmacogenomics Journal]
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Grafanaki, K., Skeparnias, I., Kontos, C. K., Anastasakis, D., Korfiati, A., Kyriakopoulos, G., Theofilatos, K., Mavroudi, S., Magoulas, G., Papaioannou, D., Scorilas, A., Stathopoulos, C., & Drainas, D. (2021). Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes. The Pharmacogenomics Journal, 1–11. https://doi.org/10.1038/s41397-021-00241-9 Cite
