Identified through screening for cancer-specific endogenous retroviral transcripts, scientists showed that the little-studied E3 ubiquitin ligase HECTD2 exerted dominant control of tumor progression in melanoma.
[Oncogene]
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Ottina, E., Panova, V., Doglio, L., Kazachenka, A., Cornish, G., Kirkpatrick, J., Attig, J., Young, G. R., Litchfield, K., Lesluyes, T., Loo, P. V., Swanton, C., MacRae, J., Tüting, T., & Kassiotis, G. (2021). E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion. Oncogene, 1–12. https://doi.org/10.1038/s41388-021-01885-4 Cite
