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Apoptosis-Inducing Anti-HER2 Agents Operate through Oligomerization-Induced Receptor Immobilization

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The authors investigated how the spatiotemporal receptor organization at the cell surface was modulated by biparatopic designed ankyrin repeat proteins (bipDARPins), which potently induced apoptosis in human epidermal growth factor receptor 2-addicted breast cancer cell lines.
[Communications Biology]
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