Using a transcriptome-wide profiling approach to map translation initiation start sites in human beta-cells under standard and inflammatory conditions, researchers identified a completely new set of polypeptides derived from non-canonical start sites and translation initiation within lncRNA.
[Diabetes]
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Thomaidou, S., Slieker, R. C., Slik, A. R. van der, Boom, J., Mulder, F., Munoz-Garcia, A., Hart, L. M. ’t, Koeleman, B., Carlotti, F., Hoeben, R. C., Roep, B. O., Mei, H., & Zaldumbide, A. (2021). Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape. Diabetes. https://doi.org/10.2337/db20-1122 Cite
