The effects of prodrug 1 were studied in lipopolysaccharide-induced in vitro and in vivo apoptosis and pancreatitis models by determining the cellular apoptotic levels with human umbilical vein endothelial cells and pancreatic caspase-3/-7 activity in mice.
[Chemico-Biological interactions]
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Hemocompatible L-Type Amino acid Transporter 1 (LAT1)-Utilizing Prodrugs of Perforin Inhibitors Can Accumulate into the Pancreas and Alleviate Inflammation-induced Apoptosis. (2021). Chemico-Biological Interactions, 109560. https://doi.org/10.1016/j.cbi.2021.109560 Cite
