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Focused CRISPR-Cas9 Genetic Screening Reveals USO1 as a Vulnerability in B-Cell Acute Lymphoblastic Leukemia

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CRISPR/Cas9-mediated disruption of USO1 in MLL-translocated B-cell acute lymphoblastic leukemia cells reduced cell growth, promoted cell death, and altered the cell cycle.
[Scientific Reports]
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