Scientists characterized the immune processes induced by the epithelium after urban particulate matter exposure in special regard to interactions with monocyte-derived dendritic cells and monocyte-derived macrophages in obstructive lung diseases.
[Scientific Reports]
7753456
{7753456:8EFNCKSC}
apa
50
1
163832
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-54ac2e8484c9372414f90b558f001d5b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228EFNCKSC%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Paplinska-Goryca%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPaplinska-Goryca%2C%20M.%2C%20Misiukiewicz-Stepien%2C%20P.%2C%20Proboszcz%2C%20M.%2C%20Nejman-Gryz%2C%20P.%2C%20Gorska%2C%20K.%2C%20Zajusz-Zubek%2C%20E.%2C%20%26amp%3B%20Krenke%2C%20R.%20%282021%29.%20Interactions%20of%20nasal%20epithelium%20with%20macrophages%20and%20dendritic%20cells%20variously%20alter%20urban%20PM-induced%20inflammation%20in%20healthy%2C%20asthma%20and%20COPD.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2013259.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92626-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92626-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D8EFNCKSC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Interactions%20of%20nasal%20epithelium%20with%20macrophages%20and%20dendritic%20cells%20variously%20alter%20urban%20PM-induced%20inflammation%20in%20healthy%2C%20asthma%20and%20COPD%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Magdalena%22%2C%22lastName%22%3A%22Paplinska-Goryca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paulina%22%2C%22lastName%22%3A%22Misiukiewicz-Stepien%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malgorzata%22%2C%22lastName%22%3A%22Proboszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrycja%22%2C%22lastName%22%3A%22Nejman-Gryz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katarzyna%22%2C%22lastName%22%3A%22Gorska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elwira%22%2C%22lastName%22%3A%22Zajusz-Zubek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafal%22%2C%22lastName%22%3A%22Krenke%22%7D%5D%2C%22abstractNote%22%3A%22Urban%20particulate%20matter%20%28UPM%29%20is%20an%20important%20trigger%20of%20airway%20inflammation.%20The%20cross-talk%20between%20the%20external%20and%20internal%20matrix%20in%20the%20respiratory%20tract%20occurs%20due%20to%20the%20transepithelial%20network%20of%20macrophages%5C%2Fdendritic%20cells.%20This%20study%20characterized%20the%20immune%20processes%20induced%20by%20the%20epithelium%20after%20UPM%20exposure%20in%20special%20regard%20to%20interactions%20with%20monocyte-derived%20dendritic%20cells%20%28moDCs%29%20and%20monocyte-derived%20macrophages%20%28moM%5Cu03c6s%29%20in%20obstructive%20lung%20diseases.%20A%20triple-cell%20co-culture%20model%20%288%20controls%2C%2010%20asthma%2C%20and%208%20patients%20with%20COPD%29%20utilized%20nasal%20epithelial%20cells%2C%20along%20with%20moM%5Cu03c6s%2C%20and%20moDCs%20was%20exposed%20to%20UPM%20for%2024%5Cu00a0h.%20The%20inflammatory%20response%20of%20nasal%20epithelial%20cells%20to%20UPM%20stimulation%20is%20affected%20differently%20by%20cell%5Cu2013cell%20interactions%20in%20healthy%20people%2C%20asthma%20or%20COPD%20patients%20of%20which%20the%20interactions%20with%20DCs%20had%20the%20strongest%20impact%20on%20the%20inflammatory%20reaction%20of%20epithelial%20cells%20after%20UPM%20exposure.%20The%20epithelial%20remodeling%20and%20DCs%20dysfunction%20might%20accelerate%20the%20inflammation%20after%20air%20pollution%20exposure%20in%20asthma%20and%20COPD.%22%2C%22date%22%3A%222021-06-24%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-92626-w%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-92626-w%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-24T16%3A59%3A32Z%22%7D%7D%5D%7D
Paplinska-Goryca, M., Misiukiewicz-Stepien, P., Proboszcz, M., Nejman-Gryz, P., Gorska, K., Zajusz-Zubek, E., & Krenke, R. (2021). Interactions of nasal epithelium with macrophages and dendritic cells variously alter urban PM-induced inflammation in healthy, asthma and COPD. Scientific Reports, 11(1), 13259. https://doi.org/10.1038/s41598-021-92626-w Cite
