Scientists showed that TNF-α strongly induced human endothelial cells to undergo Endothelial–mesenchymal transition. They also showed that TNF-α-induced EndMT was reversible. Furthermore, TNF-α treatment of orthotopic mice resulted in an important increase in the stroma, including cancer-associated fibroblasts.
[Cell Death & Disease]
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Zhong, Y., Yang, L., Xiong, F., He, Y., Tang, Y., Shi, L., Fan, S., Li, Z., Zhang, S., Gong, Z., Guo, C., Liao, Q., Zhou, Y., Zhou, M., Xiang, B., Li, X., Li, Y., Zeng, Z., Li, G., & Xiong, W. (2021). Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc. Signal Transduction and Targeted Therapy, 6(1), 1–13. https://doi.org/10.1038/s41392-021-00562-y Cite
