Researchers applied PRobe-based Imaging for Sequential Multiplexing (PRISM) to facilitate multiplexed imaging with facile, rapid exchange of imaging probes to analyze iPSC-derived cortical and motor neuron cultures that were relevant to psychiatric and neurodegenerative disease models, using over ten protein targets.
[Communications Biology]
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Tomov, M. L., O’Neil, A., Abbasi, H. S., Cimini, B. A., Carpenter, A. E., Rubin, L. L., & Bathe, M. (2021). Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Communications Biology, 4(1), 1–9. https://doi.org/10.1038/s42003-021-02276-x Cite
