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Osteocytes Regulate Neutrophil Development through IL-19: A Potent Cytokine for Neutropenia Treatment

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Mice with constitutive activation of mechanistic target of rapamycin complex signaling in osteocytes exhibited a dramatic increase in IL-19 production and promyelocyte/myelocytic expansion, whereas mTORC1 inactivation in osteocytes reduced IL-19 production and neutrophil numbers in mice.
[Blood]

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