Researchers demonstrated that AP-2alpha facilitated melanoma metastasis through transcriptional activation of genes within the E2F pathway including EZH2.
[Cancer Research]
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White, J. R., Thompson, D. T., Koch, K. E., Kiriazov, B. S., Beck, A. C., Heide, D. M. van der, Grimm, B. G., Kulak, M. V., & Weigel, R. J. (2021). AP-2alpha-mediated activation of E2F and EZH2 drives melanoma metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0772 Cite
