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The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells

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Researchers showed that treatment with the antiandrogen enzalutamide—a well-tolerated drug widely used in advanced prostate cancer—reducesd transmembrane serine protease 2 (TMPRSS2) levels in human lung cells and in mouse lung.
[Nature Communications]
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