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Gene Therapy Knockdown of Hippo Signaling Induces Cardiomyocyte Renewal in Pigs after Myocardial Infarction

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Researchers investigated an adeno-associated virus 9–based gene therapy to locally knock down the Hippo pathway gene Salvador in border zone cardiomyocytes in a pig model of ischemia/reperfusion-induced myocardial infarction.
[Science Translational Medicine]
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