Coordinated Changes in Gene Expression Kinetics Underlie Both Mouse and Human Erythroid Maturation

Using scRNA-Seq analysis of chimeric mouse embryos lacking the major erythroid regulator Gata1, scientists showed that genes with the step-changes in expression dynamics during erythroid differentiation failed to be upregulated in the mutant cells, thus underscoring the coordination of modulating transcription rate along a differentiation trajectory.