Scientists showed that cerebrovascular endothelial cell-specific deletion of Pten resulted in a dramatic increase in vesicular transcytosis by the reduction of major facilitator superfamily domain-containing 2a, leading to increased transcellular permeability of the blood-brain barrier.
[Cell Reports]
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Cui, Y., Wang, Y., Song, X., Ning, H., Zhang, Y., Teng, Y., Wang, J., & Yang, X. (2021). Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability. Cell Reports, 36(1). https://doi.org/10.1016/j.celrep.2021.109327 Cite
