Home Newsletters Neural Cell News VLM Catecholaminergic Neurons Control Tumor Growth by Regulating CD8+ T Cells

VLM Catecholaminergic Neurons Control Tumor Growth by Regulating CD8+ T Cells

0
Researchers reported that ventrolateral medulla (VLM) catecholaminergic neurons in the mouse brain were activated in tumor-bearing mice and the activity of these neurons significantly altered tumor growth in multiple syngeneic and spontaneous mouse tumor models.
[Proceedings of the National Academy of Sciences of the United States of America]
7753456 {7753456:TUTZS2Z6} apa 50 1 164294 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-a3a93413ddc5f3a35dfe61c9e3b7bf9e%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TUTZS2Z6%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20Z.%2C%20Li%2C%20Y.%2C%20Lv%2C%20X.%2C%20Zhao%2C%20L.%2C%20%26amp%3B%20Wang%2C%20X.%20%282021%29.%20VLM%20catecholaminergic%20neurons%20control%20tumor%20growth%20by%20regulating%20CD8%2B%20T%20cells.%20%3Ci%3EProceedings%20of%20the%20National%20Academy%20of%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E118%3C%5C%2Fi%3E%2828%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2103505118%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1073%5C%2Fpnas.2103505118%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DTUTZS2Z6%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22VLM%20catecholaminergic%20neurons%20control%20tumor%20growth%20by%20regulating%20CD8%2B%20T%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ze%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yehua%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xueyuan%22%2C%22lastName%22%3A%22Lv%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linlin%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaodong%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22%3Cp%3EIt%20is%20known%20that%20tumor%20growth%20can%20be%20influenced%20by%20the%20nervous%20system.%20It%20is%20not%20known%2C%20however%2C%20if%20tumors%20communicate%20directly%20with%20the%20central%20nervous%20system%20%28CNS%29%20or%20if%20such%20interactions%20may%20impact%20tumor%20growth.%20Here%2C%20we%20report%20that%20ventrolateral%20medulla%20%28VLM%29%20catecholaminergic%20%28CA%29%20neurons%20in%20the%20mouse%20brain%20are%20activated%20in%20tumor-bearing%20mice%20and%20the%20activity%20of%20these%20neurons%20significantly%20alter%20tumor%20growth%20in%20multiple%20syngeneic%20and%20spontaneous%20mouse%20tumor%20models.%20Specific%20ablation%20of%20VLM%20CA%20neurons%20by%20a%20dopamine-%5Cu03b2-hydroxylase%20%28DBH%29%20promotor-activated%20apoptosis-promoting%20caspase-3%20in%20%3Ci%3EDbh-Cre%3C%5C%2Fi%3E%20mice%20as%20well%20as%20inhibition%20of%20these%20neurons%20by%20a%20chemogenetic%20method%20slowed%20tumor%20progression.%20Consistently%2C%20chemogenetic%20activation%20of%20VLM%20CA%20neurons%20promoted%20tumor%20growth.%20The%20tumor%20inhibition%20effect%20of%20VLM%20CA%20neuron%20ablation%20is%20mitigated%20in%20%3Ci%3EDbh-Cre%3BRag1%3C%5C%2Fi%3E%3Csup%3E%3Ci%3E%5Cu2212%5C%2F%5Cu2212%3C%5C%2Fi%3E%3C%5C%2Fsup%3E%20mice%2C%20indicating%20that%20this%20regulatory%20effect%20is%20mediated%20by%20the%20adaptive%20immune%20system.%20Specific%20depletion%20of%20CD8%3Csup%3E%2B%3C%5C%2Fsup%3E%20T%20cells%20using%20an%20anti-CD8%3Csup%3E%2B%3C%5C%2Fsup%3E%20antibody%20also%20mitigated%20the%20tumor%20suppression%20resulting%20from%20the%20VLM%20CA%20neuron%20ablation.%20Finally%2C%20we%20showed%20that%20the%20VLM%20CA%20neuronal%20ablation%20had%20an%20additive%20antitumor%20effect%20with%20paclitaxel%20treatment.%20Collectively%2C%20our%20study%20uncovered%20the%20role%20of%20VLM%20CA%20neurons%20in%20the%20mouse%20brain%20in%20controlling%20tumor%20growth%20in%20the%20mouse%20body.%3C%5C%2Fp%3E%22%2C%22date%22%3A%222021%5C%2F07%5C%2F13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1073%5C%2Fpnas.2103505118%22%2C%22ISSN%22%3A%220027-8424%2C%201091-6490%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.pnas.org%5C%2Fcontent%5C%2F118%5C%2F28%5C%2Fe2103505118%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-07T15%3A20%3A03Z%22%7D%7D%5D%7D
Zhang, Z., Li, Y., Lv, X., Zhao, L., & Wang, X. (2021). VLM catecholaminergic neurons control tumor growth by regulating CD8+ T cells. Proceedings of the National Academy of Sciences, 118(28). https://doi.org/10.1073/pnas.2103505118 Cite
Full Article
Exit mobile version