Using cell-type-resolved genomics, scientists showed that comprehensive alterations in hepatocyte genomic and transcriptional settings during non-alcoholic steatohepatitis progression, led to a loss of hepatocyte identity.
[Cell Metabolism]
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Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., Wolff, G., Sakurai, M., Berutti, R., Üstünel, B. E., Nawroth, P., Ravnskjaer, K., Diaz, M. B., Blagoev, B., & Herzig, S. (2021). Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2021.06.005 Cite
