Scientists showed that TNF-α significantly reduced the expression of SIRT6 protein and mRNA in a concentration- and time-dependent manner and increased the expression of monocyte chemotactic protein 1, interleukin (IL) -6 and IL-1β in human umbilical vein endothelial cells.
[International Immunopharmacology]
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He, Y., Yang, G., Sun, L., Gao, H., Yao, F., Jin, Z., Zheng, Z., Chen, L., Wang, W., Zheng, N., & Lin, R. (2021). SIRT6 inhibits inflammatory response through regulation of NRF2 in vascular endothelial cells. International Immunopharmacology, 99, 107926. https://doi.org/10.1016/j.intimp.2021.107926 Cite
