Researchers showed that engineering of a medium-length CAR spacer enhances the therapeutic efficacy of human erb-b2 receptor tyrosine kinase 2 (HER2)-specific CAR T cells in an orthotopic xenograft medulloblastoma model.
[Nature Medicine]
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Vitanza, N. A., Johnson, A. J., Wilson, A. L., Brown, C., Yokoyama, J. K., Künkele, A., Chang, C. A., Rawlings-Rhea, S., Huang, W., Seidel, K., Albert, C. M., Pinto, N., Gust, J., Finn, L. S., Ojemann, J. G., Wright, J., Orentas, R. J., Baldwin, M., Gardner, R. A., … Park, J. R. (2021). Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis. Nature Medicine, 1–9. https://doi.org/10.1038/s41591-021-01404-8 Cite
