Home Newsletters Cell Therapy News Dexamethasone Enhances the Lung Metastasis of Breast Cancer via a PI3K-SGK1-CTGF Pathway

Dexamethasone Enhances the Lung Metastasis of Breast Cancer via a PI3K-SGK1-CTGF Pathway

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Ligation of Dex and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 expression, and then increased the expression of connective tissue growth factor through Nedd4l-Smad2.
[Oncogene]
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