Mutant IDH2 (mIDH2) R140Q commonly had K413 acetylation, which negatively regulated mIDH2 activity in human acute myeloid leukemia (AML) cells by attenuating dimerization and blocking binding of substrate (α-ketoglutarate) and cofactor (NADPH).
[Molecular Cell]
7992332
{7992332:RATC777R}
apa
50
1
164748
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
