Home Newsletters Human Immunology News BATF and IRF4 Cooperate to Counter Exhaustion in Tumor-Infiltrating CAR T Cells

BATF and IRF4 Cooperate to Counter Exhaustion in Tumor-Infiltrating CAR T Cells

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Overexpression of BATF in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, and decreased the expression of inhibitory receptors.
[Nature Immunology]
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