Researchers identified that Forkhead box protein O1 (Foxo1) regulates mucus secretion by goblet cells and determines intestinal homeostasis. Loss of Foxo1 in intestinal epithelial cells resulted in defects in goblet cell autophagy and mucus secretion, leading to an impaired gut microenvironment and dysbiosis.
[Journal of Experimental Medicine]
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Chen, Z., Luo, J., Li, J., Kim, G., Chen, E. S., Xiao, S., Snapper, S. B., Bao, B., An, D., Blumberg, R. S., Lin, C., Wang, S., Zhong, J., Liu, K., Li, Q., Wu, C., & Kuchroo, V. K. (2021). Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion. Journal of Experimental Medicine, 218(9). https://doi.org/10.1084/jem.20210324 Cite
