SNO-GNAI2 acted by coupling with CXCR5 to dephosphorylate the Hippo pathway kinase LATS1, thereby leading to nuclear translocation of YAP and promoting an inflammatory response in endothelial cells.
[Nature Communications]
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Chao, M.-L., Luo, S., Zhang, C., Zhou, X., Zhou, M., Wang, J., Kong, C., Chen, J., Lin, Z., Tang, X., Sun, S., Tang, X., Chen, H., Wang, H., Wang, D., Sun, J.-P., Han, Y., Xie, L., & Ji, Y. (2021). S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nature Communications, 12(1), 4452. https://doi.org/10.1038/s41467-021-24736-y Cite
