Scientists found that L-SIGN was highly expressed on human liver sinusoidal endothelial cells and lymph node lymphatic endothelial cells but not on blood endothelial cells.
[JCI Insight]
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Kondo, Y., Larabee, J. L., Gao, L., Shi, H., Shao, B., Hoover, C. M., McDaniel, J. M., Ho, Y.-C., Silasi-Mansat, R., Archer-Hartmann, S. A., Azadi, P., Srinivasan, R. S., Rezaie, A. R., Borczuk, A., Laurence, J. C., Lupu, F., Ahamed, J., McEver, R. P., Papin, J. F., … Xia, L. (2021). L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus. JCI Insight, 6(14). https://doi.org/10.1172/jci.insight.148999 Cite
