Home Newsletters Human Immunology News Increase in Polymorphonuclear Myeloid-Derived Suppressor Cells and Regulatory T-Cells in Children with...

Increase in Polymorphonuclear Myeloid-Derived Suppressor Cells and Regulatory T-Cells in Children with B-Cell Acute Lymphoblastic Leukemia

0
Scientists observed a reduction in the levels of CD4+ T cells and an increase in both the polymorphonuclear MDSCs and Tregs.
[Scientific Reports]
6445218 {6445218:QNTKE8BE} apa 50 1 164920 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-29cc60449a15a4c858c464819509c453%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22QNTKE8BE%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zahran%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-22%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZahran%2C%20A.%20M.%2C%20Shibl%2C%20A.%2C%20Rayan%2C%20A.%2C%20Mohamed%2C%20M.%20A.%20E.%20H.%2C%20Osman%2C%20A.%20M.%20M.%2C%20Saad%2C%20K.%2C%20Mahmoud%2C%20K.%20H.%2C%20Ghandour%2C%20A.%20M.%20A.%2C%20Elsayh%2C%20K.%20I.%2C%20%26amp%3B%20El-Badawy%2C%20O.%20%282021%29.%20Increase%20in%20polymorphonuclear%20myeloid-derived%20suppressor%20cells%20and%20regulatory%20T-cells%20in%20children%20with%20B-cell%20acute%20lymphoblastic%20leukemia.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2015039.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-94469-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-94469-x%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DQNTKE8BE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Increase%20in%20polymorphonuclear%20myeloid-derived%20suppressor%20cells%20and%20regulatory%20T-cells%20in%20children%20with%20B-cell%20acute%20lymphoblastic%20leukemia%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asmaa%20M.%22%2C%22lastName%22%3A%22Zahran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Azza%22%2C%22lastName%22%3A%22Shibl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amal%22%2C%22lastName%22%3A%22Rayan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mohamed%20Alaa%20Eldeen%20Hassan%22%2C%22lastName%22%3A%22Mohamed%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amira%20M.%20M.%22%2C%22lastName%22%3A%22Osman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khaled%22%2C%22lastName%22%3A%22Saad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khaled%20Hashim%22%2C%22lastName%22%3A%22Mahmoud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aliaa%20M.%20A.%22%2C%22lastName%22%3A%22Ghandour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Khalid%20I.%22%2C%22lastName%22%3A%22Elsayh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Omnia%22%2C%22lastName%22%3A%22El-Badawy%22%7D%5D%2C%22abstractNote%22%3A%22Our%20study%20aimed%20to%20evaluate%20the%20levels%20of%20MDSCs%20and%20Tregs%20in%20pediatric%20B-cell%20acute%20lymphoblastic%20leukemia%20%28B-ALL%29%2C%20their%20relation%20to%20patients%5Cu2019%20clinical%20and%20laboratory%20features%2C%20and%20the%20impact%20of%20these%20cells%20on%20the%20induction%20response.%20This%20study%20included%2031%20pediatric%20B-ALL%20patients%20and%2027%20healthy%20controls.%20All%20patients%20were%20treated%20according%20to%20the%20protocols%20of%20the%20modified%20St.%20Jude%20Children%5Cu2019s%20Research%20Hospital%20total%20therapy%20study%20XIIIB%20for%20ALL.%20Levels%20of%20MDSCs%20and%20Tregs%20were%20analyzed%20using%20flow%20cytometry.%20We%20observed%20a%20reduction%20in%20the%20levels%20of%20CD4%5Cu2009%2B%5Cu2009T-cells%20and%20an%20increase%20in%20both%20the%20polymorphonuclear%20MDSCs%20%28PMN-MDSCs%29%20and%20Tregs.%20The%20frequencies%20of%20PMN-MDSCs%20and%20Tregs%20were%20directly%20related%20to%20the%20levels%20of%20peripheral%20and%20bone%20marrow%20blast%20cells%20and%20CD34%5Cu2009%2B%5Cu2009cells.%20Complete%20postinduction%20remission%20was%20associated%20with%20reduced%20percentages%20of%20PMN-MDSCs%20and%20Tregs%2C%20with%20the%20level%20of%20PMN-MDCs%20in%20this%20subpopulation%20approaching%20that%20of%20healthy%20controls.%20PMN-MDSCs%20and%20Tregs%20jointly%20play%20a%20critical%20role%20in%20maintaining%20an%20immune-suppressive%20state%20suitable%20for%20B-ALL%20tumor%20progression.%20Thereby%2C%20they%20could%20be%20independent%20predictors%20of%20B-ALL%20progress%2C%20and%20finely%20targeting%20both%20PMN-MDSCs%20and%20Tregs%20may%20be%20a%20promising%20approach%20for%20the%20treatment%20of%20B-ALL.%22%2C%22date%22%3A%222021-07-22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-94469-x%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-94469-x%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-22T21%3A12%3A07Z%22%7D%7D%5D%7D
Zahran, A. M., Shibl, A., Rayan, A., Mohamed, M. A. E. H., Osman, A. M. M., Saad, K., Mahmoud, K. H., Ghandour, A. M. A., Elsayh, K. I., & El-Badawy, O. (2021). Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia. Scientific Reports, 11(1), 15039. https://doi.org/10.1038/s41598-021-94469-x Cite
Full Article
Exit mobile version