Anti-Tumor Immunity in Mismatch Repair-Deficient Colorectal Cancers Requires Type I IFN–Driven CCL5 and CXCL10

The authors discovered that selective recruitment and activation of systemic CD8+ T cells into DNA mismatch repair colorectal cancers strictly depend on overexpression of CCL5 and CXCL10 due to endogenous activation of cGAS/STING and type I IFN signaling by damaged DNA.