The authors demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.
[Molecular Cancer Research]
6445218
{6445218:IB44MT45}
apa
50
1
165099
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-65e76217b34c49c6446504776d428d5e%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22IB44MT45%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3E%3Ci%3EMutant%20p53%20attenuates%20oxidative%20phosphorylation%20and%20facilitates%20cancer%20stemness%20through%20downregulating%20microRNA-200c-PCK2%20axis%20in%20basal-like%20breast%20cancer%20%7C%20Molecular%20Cancer%20Research%3C%5C%2Fi%3E.%20%28n.d.%29.%20Retrieved%20July%2028%2C%202021%2C%20from%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fmcr.aacrjournals.org%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F07%5C%2F26%5C%2F1541-7786.MCR-21-0098%27%3Ehttps%3A%5C%2F%5C%2Fmcr.aacrjournals.org%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F07%5C%2F26%5C%2F1541-7786.MCR-21-0098%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DIB44MT45%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Mutant%20p53%20attenuates%20oxidative%20phosphorylation%20and%20facilitates%20cancer%20stemness%20through%20downregulating%20microRNA-200c-PCK2%20axis%20in%20basal-like%20breast%20cancer%20%7C%20Molecular%20Cancer%20Research%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fmcr.aacrjournals.org%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F07%5C%2F26%5C%2F1541-7786.MCR-21-0098%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-28T02%3A01%3A25Z%22%7D%7D%5D%7D
Mutant p53 attenuates oxidative phosphorylation and facilitates cancer stemness through downregulating microRNA-200c-PCK2 axis in basal-like breast cancer | Molecular Cancer Research. (n.d.). Retrieved July 28, 2021, from https://mcr.aacrjournals.org/content/early/2021/07/26/1541-7786.MCR-21-0098 Cite
