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Single-Cell Immunoblotting Resolves Estrogen Receptor-α Isoforms in Breast Cancer

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To scrutinize hormone response heterogeneity among breast cancer (BCa) tumor cells, scientists developed a precision tool to specifically measure estrogen receptor alpha (ER-α)-66, ER-α46, and eight ER-signaling proteins with single-cell resolution in the highly hetero-clonal MCF-7 BCa cell line.
[PLoS One]
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