With the help of cell cytotoxicity, the effect of tonkinensine B on MDA-MB-231 cells was investigated. The levels of key apoptosis-associated proteins Bcl-2, Bax, caspase-9, caspase-3 and AKT in MDA-MB-231 cells were analysed to determine whether tonkinensine B caused apoptosis via the mitochondrial pathway.
[Journal of Pharmacy and Pharmacology]
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Sun, X., Zhang, T., Cai, Y., Yang, K., Peng, T., Liu, R., & Li, X.-N. (2021). Tonkinensine B induces apoptosis through mitochondrial dysfunction and inactivation of the PI3K/AKT pathway in triple-negative breast cancer cells. Journal of Pharmacy and Pharmacology, rgab108. https://doi.org/10.1093/jpp/rgab108 Cite
