Researchers harnessed CRISPR-Cas9 gene editing technology to introduce a mutation at cysteine 277 in the active site of the mouse Tgm2 gene. In vitro, a remodeling stimulus led to the significant loss of vascular compliance in wild-type mice, but not in the Tgm2-C277S or TG2−/− mice.
[Cell Death Discovery]
7992332
{7992332:RV6VGF4N}
apa
50
1
165175
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