Bisthianostat dose dependently induced acetylation of tubulin and H3 and increased PARP cleavage and apoptosis in RPMI-8226 cells. In RPMI-8226 and MM.1S cell xenograft mouse models, oral administration of bisthianostat for 18 days dose dependently inhibited tumor growth.
[Acta Pharmacologica Sinica]
7992332
{7992332:48KLC7GE}
apa
50
1
165226
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