Using ex vivo human primary T cells, researchers found that PIP4K activity was required for Treg cell signaling and immunosuppressive activity. Genetic and pharmacological inhibition of PIP4K in Tregs reduced signaling through the PI3K, mTORC1/S6, and MAPK pathways, impaired cell proliferation, and increasedactivation-induced cell death while sparing Tconv.
[Proceedings of the National Academy of Sciences of the United States of America]
6445218
{6445218:QZL9DKTA}
apa
50
1
165243
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