To establish a benchmark of human Treg dysfunction, researchers targeted the master transcription factor FOXP3 in naive and memory Tregs. Although FOXP3-ablated Tregs upregulated cytokine expression, effects on suppressive capacity in vitro manifested slowly and primarily in memory Tregs.
[Cell Reports]
6445218
{6445218:XEQ7UQK9}
apa
50
1
165246
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