Researchers focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes.
[Immunity]
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Mulder, K., Patel, A. A., Kong, W. T., Piot, C., Halitzki, E., Dunsmore, G., Khalilnezhad, S., Irac, S. E., Dubuisson, A., Chevrier, M., Zhang, X. M., Tam, J. K. C., Lim, T. K. H., Wong, R. M. M., Pai, R., Khalil, A. I. S., Chow, P. K. H., Wu, S. Z., Al-Eryani, G., … Ginhoux, F. (2021). Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.07.007 Cite
