Researchers demonstrated that endothelial cells (ECs) of venules in inflamed tissues exhibited a robust autophagic response that was aligned temporally with the peak of neutrophil trafficking and was strictly localized to EC contacts.
[Immunity]
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Reglero-Real, N., Pérez-Gutiérrez, L., Yoshimura, A., Rolas, L., Garrido-Mesa, J., Barkaway, A., Pickworth, C., Saleeb, R. S., Gonzalez-Nuñez, M., Austin-Williams, S. N., Cooper, D., Vázquez-Martínez, L., Fu, T., Rossi, G. D., Golding, M., Benoit-Voisin, M., Boulanger, C. M., Kubota, Y., Muller, W. A., … Nourshargh, S. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.07.012 Cite
