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Hyperleptinemia in Obese State Renders Luminal Breast Cancers Refractory to Tamoxifen by Coordinating a Crosstalk between Med1, miR205 and ErbB

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Exogenous leptin abrogated tamoxifen-mediated growth inhibition and potentiated breast tumor growth even in the presence of tamoxifen.
[npj Breast Cancer]
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