CD4+ T Cells in the Lungs of Acute Sarcoidosis Patients Recognize an Aspergillus nidulans Epitope

The authors screened related Löfgren’s syndrome-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner.