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Signaling Profiles in HEK 293T Cells Co-Expressing GLP-1 and GIP Receptors

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Scientists showed that when the two receptors were co-expressed in HEK 293T cells with comparable receptor ratio to pancreatic cancer cells, glucose-dependent insulinotropic polypeptide (GIP) predominately induced cAMP accumulation while Glucagon-like peptide-1 (GLP-1) was biased towards β-arrestin 2 recruitment.
[Acta Pharmacologica Sinica]

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Abstract
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