Using multiplex immunofluorescence staining in cohorts of anti-PD-1 and anti-PD-L1-treated lung cancer patients, scientists showed that decreased expression of cancer cell αV was associated with improved immunotherapy-related, progression-free survival.
[Nature Communications]
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Malenica, I., Adam, J., Corgnac, S., Mezquita, L., Auclin, E., Damei, I., Grynszpan, L., Gros, G., de Montpréville, V., Planchard, D., Théret, N., Besse, B., & Mami-Chouaib, F. (2021). Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade. Nature Communications, 12(1), 5209. https://doi.org/10.1038/s41467-021-25322-y Cite
