Scientists investigated the role of microbiota-derived lactate in hematopoiesis using mice deficient in G-protein-coupled receptor (Gpr) 81 (Gpr81−/−), an established lactate receptor. They detected significant depletion of total HSCs in the bone marrow of Gpr81−/− mice compared with heterogenic mice in a steady state.
[Experimental and Molecular Medicine]
7992332
{7992332:BBBBBBBB}
apa
50
1
166607
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