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A Microfluidic Approach to Rescue ALS Motor Neuron Degeneration Using Rapamycin

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Scientists presented a transgenic, TAR DNA-binding protein-43 (TDP-43)-A315T, mouse model expressing an Amyotrophic Lateral Sclerosis (ALS) phenotype and demonstrated the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.
[Scientific Reports]
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