Home Newsletters Hematopoiesis News Enhancer Recruitment of Transcription Repressors RUNX1 and TLE3 by Mis-Expressed FOXC1 Blocks...

Enhancer Recruitment of Transcription Repressors RUNX1 and TLE3 by Mis-Expressed FOXC1 Blocks Differentiation in Acute Myeloid Leukemia

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Scientists highlighted RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and revealed that FOXC1 prevented this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.
[Cell Reports]
7992332 {7992332:BBBBBBBB} apa 50 1 166973 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
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