Researchers demonstrated that an increased physical rigidity of a fibroblast’s environment was sufficient to evoke stromal autophagy. Mechanistically, matrix stiffness was transmitted via Integrin αV receptors and focal adhesion kinase, resulting in stabilization of AMPK at focal adhesion structures.
[Proceedings of the National Academy of Sciences of the United States of America]
7992332
{7992332:CCCCCCCC}
apa
50
1
167570
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