Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes

Researchers hypothesized that progressive changes in gene expression resulted in malignant transformation of B lymphocytes to family histroy of monoclonal B lymphocytosis, and subsequent alterations in gene expression occur before overt family history of chronic lymphocytic leukemia develops.