Oridonin Inhibits DNMT3A R882 Mutation-Driven Clonal Hematopoiesis and Leukemia by Inducing Apoptosis and Necroptosis

Researchers performed high-throughput screening and identified that oridonin, an ent-kaurene diterpenoid extracted from the Chinese herb Rabdosia rubescens, inhibited DNMT3A R882 mutant leukemic cells at a low-micromolar concentration.