Metabolic Profiling of Attached and Detached Metformin and 2-Deoxy-D-Glucose Treated Breast Cancer Cells Reveals Adaptive Changes in Metabolome of Detached Cells

Scientists performed LC/MS metabolic profiling on separated attached and detached MDA-MB-231 cells treated with metformin and/or 2-deoxy-D-glucose and found that the metabolic profile of detached cells was closer to untreated control cells, suggesting detachment might help cells adapt to energy stress.