A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

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The authors presented a humanized animal model of myelofibrosis patient-derived xenografts which were robustly engrafted patient cells that recapitulated the patient’s genetic hierarchy and pathologies such as reticulin fibrosis and propagation of myeloproliferative neoplasms-initiating stem cells.
[Cancer Discovery]

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Abstract