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Bioorthogonal Labeling of Transmembrane Proteins with Non-canonical Amino Acids Unveils Masked Epitopes in Live Neurons

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Investigators reported the development of a complete labeling and imaging pipeline using genetic code expansion and non-canonical amino acids in neurons that allows to fluorescently label masked epitopes in target transmembrane proteins in live neurons, both in dissociated culture and organotypic brain slices.
[Nature Communications]

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